478 Haemodynamics Following Intravenous Paracetamol Administration in (PRE) Term Neonates

Clinical Pharmacology of Intravenous Paracetamol in Neonates

Effective analgesia in neonates is still hampered due to the lack of data on pharmacokinetics and –dynamics of analgesics in this specific population. To a certain extent, this is even true for paracetamol. An intravenous formulation might improve prediction of concentration and consequent effect compared to enteral administration. In this review, we summarize the consecutive steps reported in ...

Pain relief in neonates: when to use intravenous paracetamol.

Pharmacokinetics of Cefepime Following Intravenous and Intramuscular Administration in Sheep

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An Investigation of Safety and Efficacy of Intravenous Paracetamol in Pain Management Following Cardiac Surgery

Introduction: Optimum pain management immediately after surgeries can lower the possibility of pain syndrome and its following consequences. Opioids are amongst the analgesics used for postoperative pain control; however, their application can bring about several adverse effects. In this study, all the published articles regarding efficacy of Paracetamol   in post-cardiac surgery pain managemen...

Pharacokinetics and Urinary Excretion of Paracetamol following Intravenous Administration in Buffalo Calves

Pharmacokinetic study of paracetamol was conducted in five female buffalo calves following single i.v. injection of paracetamol @ 40 mg/kg. The drug was detected up to 2 h only in plasma, while it was detected for a longer period of 48 h in urine with a mean concentration of 1.87 ± 0.48 and 10.90 ± 1.14 mg/ml, respectively. The mean distribution half life (t 1/2 α) of 0.11 ± 0.01 h and eliminat...